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Updated: Feb 26, 2026

Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding

Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding

Published on: November 14, 2018

肥満におけるオキシトシン作動性経路の神経内分泌的役割

Xueqin Liu¹, Yunfeng Chen¹, Yanmei Huang²

¹Department of Metabolism and Endocrinology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.

Clinical endocrinology

|February 25, 2026

Abstract:

Oxytocin (OXT) and its neuronal system demonstrate significant therapeutic potential for obesity and related metabolic disorders. Preclinical studies indicate that OXT promotes weight loss by suppressing food intake, enhancing energy expenditure, and stimulating lipolysis. However, clinical trial results have been heterogeneous, and challenges such as long-term safety concerns and difficulties in dose control hinder its clinical translation. Further elucidation of the neuroendocrine interactions between oxytocinergic neurons and metabolic regulation, along with exploration of targeted neuronal activity modulation, may provide critical breakthroughs for developing effective and safe obesity treatments.

キーワード:

エネルギー代謝食物摂取肥満オキシトシンオキシトシン作動性ニューロン

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