Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

646
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
646
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

7.0K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
7.0K
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

852
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
852
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

602
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
602
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

762
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
762
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

1.2K
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
1.2K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Familial benign recurrent acral pigmentation: A rare presentation.

JAAD case reports·2026
Same author

Gene expression and microsecond scale conformational dynamics suggest potential regulatory mechanisms for the expanded subtilase family of <i>T. rubrum</i>.

Journal of biomolecular structure & dynamics·2026
Same author

Bioinspired antimicrobial glass coatings for clear and infection-resistant surfaces.

Journal of materials chemistry. B·2026
Same author

Rising Stars in Infectious Diseases Research: Celebrating Our Early Career Awardees.

ACS infectious diseases·2026
Same author

ACS @150: Role of Medicinal Chemistry in Antibacterial Drug Discovery.

ACS infectious diseases·2026
Same author

Call for Papers: Medicinal Chemistry and Pharmacology of Antiviral Drugs.

Journal of medicinal chemistry·2026

関連する実験動画

Updated: Feb 26, 2026

Author Spotlight: Advancing Therapeutics to Treat Vibriosis in Humans and Aquatic Organisms
03:29

Author Spotlight: Advancing Therapeutics to Treat Vibriosis in Humans and Aquatic Organisms

Published on: May 31, 2024

989

抗菌活性および過剰炎症緩和のための四級チオマー

Dipanjana Patra1,2, Sayan Chakravarty2, Himani Singh2

  • 1Chemistry and Physics of Materials Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Jakkur, Bengaluru, Karnataka 560064, India.

ACS infectious diseases
|February 25, 2026
PubMed
まとめ

新規四級チオレート化ポリマー（QTP）は、薬剤耐性菌およびバイオフィルムを効果的に抑制する。この広範な抗菌剤は、炎症を軽減し創傷治癒を促進するため、難治性感染症に対する有望な解決策となる。

キーワード:
抗酸化剤殺菌剤バイオフィルム過剰炎症表在性創傷感染チオマー

さらに関連する動画

Author Spotlight: Scalable Drug Screening Protocol for Efficient Discovery of M. abscessus Treatments
07:50

Author Spotlight: Scalable Drug Screening Protocol for Efficient Discovery of M. abscessus Treatments

Published on: October 25, 2024

2.5K
Facilitating Drug Discovery: An Automated High-content Inflammation Assay in Zebrafish
07:50

Facilitating Drug Discovery: An Automated High-content Inflammation Assay in Zebrafish

Published on: July 16, 2012

14.8K

関連する実験動画

Last Updated: Feb 26, 2026

Author Spotlight: Advancing Therapeutics to Treat Vibriosis in Humans and Aquatic Organisms
03:29

Author Spotlight: Advancing Therapeutics to Treat Vibriosis in Humans and Aquatic Organisms

Published on: May 31, 2024

989
Author Spotlight: Scalable Drug Screening Protocol for Efficient Discovery of M. abscessus Treatments
07:50

Author Spotlight: Scalable Drug Screening Protocol for Efficient Discovery of M. abscessus Treatments

Published on: October 25, 2024

2.5K
Facilitating Drug Discovery: An Automated High-content Inflammation Assay in Zebrafish
07:50

Facilitating Drug Discovery: An Automated High-content Inflammation Assay in Zebrafish

Published on: July 16, 2012

14.8K

科学分野:

  • 生体材料科学
  • 高分子化学
  • 感染症

背景:

  • 感染症の増加と抗菌選択肢の制限により、新しい広範な治療法が必要とされている。
  • スーパーバグは、感染制御を複雑にする、回復力のあるバイオフィルムを形成する。
  • キトサン誘導体は有望であるが、相乗的な修飾は十分に探求されていない。

研究 の 目的:

  • 新規四級チオレート化ポリマー（QTP）を合成および評価すること。
  • QTPの相乗的な抗菌および抗バイオフィルム特性を調査すること。
  • 創傷感染モデルにおけるQTPの有効性を評価すること。

主な方法:

  • HTCCおよびチオグリコール酸から合成された四級チオレート化ポリマー（QTP）。
  • 耐性菌に対する広範な抗菌活性を試験した。
  • 抗酸化、毒性、およびバイオフィルム阻害アッセイを実施した。
  • マウスの表在性創傷感染モデルで有効性を評価した。

主要な成果:

  • QTPは、グラム陽性菌およびグラム陰性菌に対して広範な活性を示した。
  • ポリマーは抗酸化特性と低毒性を示した。
  • QTPは細菌バイオフィルムを大幅に減少させた（>99.9%）。
  • invivoにおいて、QTPはMRSAを根絶し、皮膚の治癒を促進した。

結論:

  • QTPは、四級化とチオレート化の相乗的な組み合わせを提供する。
  • 開発されたポリマーは、耐性細菌感染に対する強力な治療候補となる。
  • QTPは、複雑な創傷感染の治療の可能性を示す。