Real-world management patterns and outcomes in normal-tension glaucoma
1Glaucoma Service, L. V. Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, Telangana, India.
Indian journal of ophthalmology
|February 25, 2026
まとめ
Real-world normal-tension glaucoma (NTG) treatment shows significant visual field progression in 22.2% of treated eyes. Current clinical factors do not predict progression, necessitating research into novel risk factors for managing NTG.
科学分野:
- Ophthalmology; Glaucoma Research; Clinical Practice
背景:
- Normal-tension glaucoma (NTG) poses challenges in real-world clinical settings.; A significant proportion of NTG patients present with advanced disease (45% severe glaucoma).
研究 の 目的:
- To evaluate clinical outcomes of normal-tension glaucoma (NTG) in real-world practice.; To analyze the clinical profile, treatment preferences, and visual field progression patterns in NTG patients.; To identify factors influencing treatment decisions and disease progression.
主な方法:
- Retrospective analysis of 875 eyes (476 patients) with NTG.; Data collection included ocular/systemic associations, medications, intraocular pressure (IOP), and visual field parameters.; Visual field progression was assessed using guided progression analysis in 496 eyes.
主要な成果:
- 45% of eyes had severe glaucoma at baseline (MD = -13 ± 8.7 dB).; 22.2% of treated eyes exhibited visual field progression over a mean follow-up of 32 months.; Progression rate in affected eyes was -2 ± 0.9 dB/year; no clinical or systemic factors predicted progression.
結論:
- Real-world NTG management faces challenges, with many patients presenting with severe disease.; The lack of identifiable predictors for visual field progression underscores the need for further research.; Discovering novel risk factors is crucial for effectively halting NTG progression.
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