馬におけるCrotalaria juncea自然中毒に関連する肺線維症

Andrezza C Andrade¹, Silvio M C Fonseca¹, Givaldo B Silva Filho¹

¹Laboratório de Diagnóstico Animal, Universidade Federal Rural de Pernambuco (UFRPE), Rua Dom Manuel de Medeiros s/n, Recife, PE 52171-900, Brazil.

Toxicon : official journal of the International Society on Toxinology

|February 25, 2026

Abstract:

We report an outbreak of Crotalaria juncea intoxication in horses exhibiting progressive weight loss and respiratory distress in northeastern Brazil. Necropsy revealed firm, non-collapsed lungs with extensive interstitial fibrosis, bronchiolar epithelial hyperplasia with club cells proliferation, and marked pulmonary arterial remodeling. Hepatic lesions consisted primarily of centrilobular necrosis, probably resulting from hypoxic injury related to anemia and prolonged agonic death. Pasture inspection identified significant invasion by shrubs of C. juncea in various phenological stages.

キーワード:

Crotalaria ウマ科肺炎ピロリジジンアルカロイド

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