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Updated: Feb 28, 2026

Screening of Axonal Degeneration in Carpal Tunnel Syndrome Using Ultrasonography and Nerve Conduction Studies

Screening of Axonal Degeneration in Carpal Tunnel Syndrome Using Ultrasonography and Nerve Conduction Studies

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糖尿病性尺骨管症候群

Iliana Stamatiou¹, Nikolaos Papanas²

¹Diabetes Centre, Second Department of Internal Medicine, Democritus University of Thrace - Alexandropoulis Campus, Alexandroupolis, Greece.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association

|February 25, 2026

Abstract:

Ulnar compression neuropathy (UCN) constitutes the second most frequent entrapment neuropathy of the upper extremities, observed with increased prevalence among diabetes mellitus (DM) patients. The metabolic burden of DM, including chronic hyperglycaemia, microvascular dysfunction, and systemic inflammation, promotes nerve susceptibility to mechanical compression. This review summarises current evidence on the association between DM and UCN, highlighting epidemiological data, metabolic contributors, clinical manifestations, diagnostic tools, and management strategies. Diagnostic evaluation in DM patients may be challenging due to coexisting polyneuropathy, necessitating a multimodal and individualized approach. Management includes both conservative measures and surgical decompression, with early intervention being critical to prevent permanent deficits. Clinicians should maintain high suspicion of UCN in DM patients to ensure timely diagnosis and improve functional outcomes in this high-risk population.

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糖尿病尺骨神経障害神経圧迫診断治療

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