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Updated: Feb 28, 2026

Identification of Novel CK2 Kinase Substrates Using a Versatile Biochemical Approach
11:11

Identification of Novel CK2 Kinase Substrates Using a Versatile Biochemical Approach

Published on: February 21, 2019

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CaMKIIαおよびCaMKIIβの両方を欠損したマウスの皮質組織のリン酸化プロテオーム解析により、新たな生体内基質が同定された

Pomme M F Rigter1,2, Karel Bezstarosti3, Oguz Can Koc4

  • 1Department of Clinical Genetics, Erasmus MC, 3015 GD Rotterdam, The Netherlands.

ACS chemical neuroscience
|February 25, 2026
PubMed
まとめ

カルシウム/カルモジュリン依存性タンパク質キナーゼII（CaMKII）は脳機能に不可欠である。本研究では、新たなCaMKII基質とリン酸化部位を同定し、脳におけるその必須の役割に関する新たな洞察を明らかにした。

キーワード:
CaMKII基質コンセンサス配列Camk2a/Camk2b二重ノックアウトカルシウム/カルモジュリン依存性タンパク質キナーゼII型アルファおよびベータ（CaMKIIαおよびCaMKIIβ）皮質生体内基質リン酸化プロテオミクス

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