関連する実験動画

Updated: Feb 28, 2026

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

輸血医療における分子検査の拡大と利用

HyoJeong Han¹, Zaina Inam², Jennifer Webb¹

¹Division of Hematology, Center for Cancer and Blood Disorders, Children's National Hospital; Division of Pathology & Laboratory Medicine, Children's National Hospital, 111 Michigan Avenue NW, WW-4, Suite 600, Washington, DC 20010, USA; Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.

Clinics in laboratory medicine

|February 25, 2026

まとめ

分子検査は、患者とドナーの血液抗原を正確に特定し、輸血の安全性向上と同種免疫の低減を実現します。この迅速な技術は、母体血中DNAを用いた胎児検査も可能にします。

背景:

安全な輸血には正確な血液抗原型判定が不可欠です。
同種免疫は、輸血レシピエントにおける重大なリスクであり続けています。
従来の抗原検査方法には時間がかかる場合があります。

結論:

分子検査は、血液抗原プロファイリングのための正確かつ効率的な方法を提供します。
この技術は、同種免疫リスクを最小限に抑えることにより、輸血の安全性を高めます。
分子アッセイは、母体血中DNAの胎児検査における応用が期待されます。

キーワード:

同種免疫抗原細胞フリーDNA Dバリアント遺伝子型ヒト白血球抗原次世代シーケンシングポリメラーゼ連鎖反応

さらに関連する動画

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

Published on: April 5, 2018

Methylation Specific Multiplex Droplet PCR using Polymer Droplet Generator Device for Hematological Diagnostics

Methylation Specific Multiplex Droplet PCR using Polymer Droplet Generator Device for Hematological Diagnostics

Published on: June 29, 2020

関連する概念動画

Blood Transfusion

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...

Blood Transfusion and Agglutination

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...

Modern Molecular Taxonomy

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...