小児薬局における「信号機」:地域薬局チームのための警告状況
Clémence Lebrun1, Audray Castet-Nicolas2, Sonia Prot-Labarthe3
1Faculty of Pharmacy Montpellier, 15 Avenue Charles Flahault, Montpellier 34000, France.
まとめ
地域薬剤師は、小児救急を管理し、専門家のアドバイスを提供する新しいツールを利用できるようになりました。この取り組みは、患者の安全性を高め、保護者を適切なケアに導くことを目的としています。
科学分野:
- Pharmacy Practice
- Pediatric Emergency Medicine
背景:
- Community pharmacists play a vital role in the safety and guidance of pediatric patients.
- Pharmacist advice significantly impacts parental decisions regarding child health.
- Specialized pediatric training is essential for pharmacists to effectively support children's health needs.
研究 の 目的:
- To develop practical tools for pharmacists, technicians, and students in pediatric community pharmacy care.
- To provide guidance for appropriate patient advice, consultations, and emergency pediatric care.
主な方法:
- A literature review and drafting of items covering pediatric pathologies, advice contexts, and emergencies were conducted.
- Items were classified into 'red' (life-threatening), 'orange' (relative emergency), and 'green' (good practice) lights.
- Expert consensus (32 pediatricians, 16 pharmacists) was achieved using a two-round method (May-July 2023).
主要な成果:
- A consensus was reached among 16 international experts (32 pediatricians, 16 pharmacists).
- The final tool comprises 53 items categorized into 35 red, 7 orange, and 11 green lights for managing pediatric situations.
- Items were refined based on expert feedback to optimize clinical utility.
結論:
- This tool is a pioneering resource for community pharmacists in pediatric emergency management.
- Future steps include dissemination, evaluation, and regular updates based on feedback.
- The tool aims to strengthen pharmacists' capacity in pediatric care, improving patient and parent outcomes.
関連する概念動画
Pharmaceutical Poisoning: Potential Scenarios
39
Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
39
Pharmacokinetics in Pediatric Patients: Drug Distribution
381
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
381
Pharmacovigilance
1.9K
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
1.9K
Pharmacokinetics in Pediatric Patients: Drug Excretion
336
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
336
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
384
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
384
Pharmacokinetics in Pediatric Patients: Drug Metabolism
289
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
289


