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Updated: Feb 28, 2026

Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice

Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice

Published on: January 16, 2015

小児期における初期アテローム性動脈硬化変化に対する親の喫煙の影響

Nesrin Coşkun¹, Öykü Tosun²

¹Department of Pediatrics, Istanbul Medeniyet Universityhttps://ror.org/05j1qpr59, Istanbul, Turkey.

Cardiology in the young

|February 26, 2026

要旨

Background And Aims:

This study aimed to evaluate the independent effect of parental smoking on early markers of atherosclerosis in children, specifically carotid intima-media thickness and epicardial adipose tissue thickness.

Methods:

A total of 106 healthy children aged 6-16 years were enrolled, including 53 with parental smoking exposure and 53 unexposed controls. Participants underwent clinical evaluation, laboratory assessment, transthoracic echocardiography, and carotid ultrasonography. Data on parental smoking habits, sociodemographic characteristics, and children's daily sleep duration were collected. Multivariable analyses were performed to assess the independent association between parental smoking and subclinical atherosclerotic markers.

Results:

Children exposed to parental smoking demonstrated significantly greater epicardial adipose tissue thickness and carotid intima-media thickness compared with controls (p = 0.014 and p = 0.001, respectively). Lipid parameters did not differ significantly between groups. Daily sleep duration was negatively correlated with epicardial adipose tissue thickness (r = -0.325, p = 0.018) and carotid intima-media thickness (r = -0.484, p < 0.001). Parental smoking remained independently associated with both markers after adjustment for relevant covariates.

Conclusions:

Parental smoking is associated with early atherosclerotic changes in children, demonstrated by increased carotid intima-media thickness and epicardial adipose tissue thickness, independent of traditional cardiovascular risk factors.

キーワード:

アテローム性動脈硬化症頸動脈内膜中膜心外膜脂肪組織親の喫煙

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