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Updated: Feb 27, 2026

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アレル選択的なフォン・ウィルブランド因子サイレンシング

Jeroen Eikenboom1, Noa Linthorst1, Yvonne Jongejan1

  • 1Department of Internal Medicine, Division of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands.

Research and practice in thrombosis and haemostasis
|February 26, 2026
PubMed
まとめ

No abstract available in PubMed .

キーワード:
RNA干渉small interfering RNA血栓症フォン・ウィルブランド病フォン・ウィルブランド因子

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
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