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肝臓への親和性を最小限に抑えた合理的に設計されたAAV9-DMキャプシド

Zoe C Nabakowski1, Izabella C Jaramillo1, Primrose Tanachaiwiwat1

  • 1Division of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, College of Medicine, Gainesville, FL 32611, USA.

Cells
|February 26, 2026
PubMed
まとめ

No abstract available in PubMed .

キーワード:
アデノ随伴ウイルスキャプシド工学遺伝子治療肝臓ターゲティング解除合理的設計

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Imperfections in Crystal Structure: Stoichiometric Point Defects

Schottky defects arise when some lattice points in a crystal, such as those in NaCl, remain unoccupied, creating lattice vacancies without disturbing the overall electrical neutrality of the crystal. This defect is common in ionic crystals where the positive and negative ions are similar in size, as seen in sodium chloride and cesium chloride. The presence of Schottky defects enables the crystal to conduct electricity to a small extent through an ionic mechanism. Electric fields cause nearby...