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Updated: Feb 27, 2026

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iPSC-CMにおけるミトコンドリア生合成の工学的設計：高度な心筋細胞開発のためのCRISPR誘導アプローチ

Dhienda C Shahannaz1,2, Tadahisa Sugiura2, Brandon E Ferrell2

  • 1Faculty of Medicine, Universitas Indonesia, Jakarta 16424, Indonesia.

Journal of cardiovascular development and disease
|February 26, 2026
PubMed
まとめ

No abstract available in PubMed .

キーワード:
CRISPR活性化（CRISPRa）PGC-1αシグナル伝達心筋細胞成熟細胞外小胞療法iPSC由来心筋細胞iPSC-CMにおける代謝コンディショニングミトコンドリア生合成ミトコンドリアダイナミクスミトコンドリアゲノム編集酸化的リン酸化（OXPHOS）

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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