脳腫瘍診断におけるPET画像品質要因の評価研究

Objectives: This retrospective, multi-center study analyzed pre-existing anonymized clinical data from electronic health records and imaging archives. The analysis utilized real-world clinical data from 200 patients across four tertiary care centers, without additional patient recruitment or interventions. This study aims to investigate the impact of metabolic and physiological factors-specifically blood glucose levels, cortisol concentrations, fasting duration, and tumor histology-on the quality and diagnostic reliability of ¹⁸F-FDG PET/CT imaging in patients with primary brain tumors and inflammatory lesions. Methods: A total of 200 patients with primary brain tumors (including astrocytoma, glioblastoma, meningioma, and oligodendroglioma) were evaluated across four institutions using standardized protocols. The study examined the effects of prolonged fasting (>12 h), hyperglycemia (>150 mg/dL), and strict fasting (4-6 h) on tumor-to-background contrast and visual analog scale (DQS) scores. Results: Prolonged fasting was associated with elevated cortisol levels (correlation +0.54, p < 0.001), while hyperglycemia significantly reduced tumor SUVmax by up to 20% (r = -0.35, p = 0.012). Strict fasting and glucose control resulted in improved tumor-to-background contrast and DQS scores (r = +0.83, p < 0.001). Glioblastomas exhibited the highest SUVmax (9.1 ± 3.5), indicating aggressive metabolic activity, whereas meningiomas showed elevated cortisol levels (20.5 ± 6.8 µg/dL) linked to disruption of the hypothalamic-pituitary axis. Regression analysis confirmed that both cortisol and glucose levels independently degraded image quality (β = -0.25 and -0.18, respectively; p < 0.05). Conclusions: The findings highlight the necessity for harmonized patient preparation protocols. Recommendations are in alignment with the SNMMI Procedure Standard/EANM Practice Guideline for Brain [¹⁸F] FDG PET imaging.