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Updated: Feb 27, 2026

Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy
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N-Lac-Pheはミトコンドリア機能不全を改善することにより心筋細胞死を軽減し、最終的にTAC誘発性心不全を改善する

Lei Sha1, Anning Du2, Xiaoying Xu1

  • 1Department of Cardiology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Zhongshan Road, Nanjing, Jiangsu, 210008, China.

Cardiovascular drugs and therapy
|February 26, 2026
PubMed
まとめ

No abstract available in PubMed .

キーワード:
アポトーシス心不全MFN2ミトコンドリアN-Lac-Phe

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Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
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