患者エンゲージメントを臨床薬理学および薬力学に統合する：データ駆動型科学への患者の声の導入

Patient engagement (PE) refers to the active partnership between researchers and patients throughout the research process. Here, we introduce a novel framework that embeds PE directly into quantitative modeling workflows, including model scoping and question framing, covariate selection, dose and regimen optimization, and interpretation of model outputs. Practical approaches such as feedback sessions and "data parties" demonstrate how integrating PE can systematically inform modeling decisions and ensure analyses remain patient-centered.