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Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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関連する実験動画

Updated: Feb 28, 2026

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

Published on: May 9, 2025

設計されたbioPROTACsによるCAR T細胞の再プログラミング

Vivek S Peche, Sebastian Kenny, Tae Gun Kang

bioRxiv : the preprint server for biology

|February 27, 2026

まとめ

新しいbioPROTACsは、CAR T細胞機能を強化するための可逆的かつ非遺伝子編集の方法を提供します。このアプローチは、次世代細胞療法の調整可能な戦略を提供するT細胞疲弊レギュレーターを標的とします。

背景:

遺伝子編集は、ネガティブレギュレーターを破壊することによってCAR T細胞機能を強化します。
既存の遺伝子編集方法は、治療的応用において限界があります。

結論:

de novo設計されたbioPROTACsは、CAR T細胞機能を強化するための実行可能で非遺伝子編集の代替を提供します。
この可逆的なアプローチは、T細胞の運命再プログラミングに対する調整可能な制御を提供します。
bioPROTACsは、次世代細胞療法の開発に広く適用可能です。

キーワード:

bioPROTACs CAR T-cell therapy T-cell exhaustion cell reprogramming non-gene editing

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Generation of Human Chimeric Antigen Receptor Regulatory T Cells

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Clinical Application of Sleeping Beauty and Artificial Antigen Presenting Cells to Genetically Modify T Cells from Peripheral and Umbilical Cord Blood

Clinical Application of Sleeping Beauty and Artificial Antigen Presenting Cells to Genetically Modify T Cells from Peripheral and Umbilical Cord Blood

Published on: February 1, 2013

関連する実験動画

Last Updated: Feb 28, 2026

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

Published on: May 9, 2025

Generation of Human Chimeric Antigen Receptor Regulatory T Cells

Generation of Human Chimeric Antigen Receptor Regulatory T Cells

Published on: January 3, 2025

Clinical Application of Sleeping Beauty and Artificial Antigen Presenting Cells to Genetically Modify T Cells from Peripheral and Umbilical Cord Blood

Clinical Application of Sleeping Beauty and Artificial Antigen Presenting Cells to Genetically Modify T Cells from Peripheral and Umbilical Cord Blood

Published on: February 1, 2013