血管化チップ上オルガノイド:灌流可能で個別化されたモデルのために
Bianca Menzani1, Priscille De Gea1, Xavier Gidrol1
1University Grenoble Alpes, CEA, Inserm, IRIG, UA13 BGE, Biomics, 38000 Grenoble, France. xavier.gidrol@cea.fr.
Lab on a chip
|February 27, 2026
まとめ
チップ上オルガノイドの血管化は、生理学的関連性と翻訳的可能性を高める。このレビューでは、成熟と相互作用の限界を克服するために、オルガノイドモデルへの灌流可能な血管系の統合戦略を探る。
背景:
- オルガノイドは、ヒトの生理学と疾患のための高度なin vitroモデルであるが、不完全な成熟や血管系の欠如といった課題に直面している。
- オルガノイドをマイクロ流体プラットフォーム(チップ上オルガノイド)に統合することは、これらの限界に対処するための制御された微小環境を提供する。
結論:
- 血管化は、チップ上オルガノイド技術を進歩させるための重要なステップである。
- 機能的な血管化されたオルガノイドの達成には、学際的なアプローチが必要である。
- この技術は、in vitro疾患モデリングと創薬を改善するために大きな可能性を秘めている。
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