界面活性剤支援法によるタングステン酸ニッケルナノ粒子の合成：神経伝達物質検出のための効率的なプラットフォーム

Accurate detection of dopamine (DPM) is critical due to its essential role in neurological function and its occurrence across diverse biological and food matrices. In this work, we report a novel cetyltrimethylammonium bromide (CTAB)-assisted synthesis of nickel tungstate nanoparticles (NiWO₄ NPs) for the electrochemical determination of DPM in food samples such as yogurt and raw chicken. The successful formation of NiWO₄ NPs was confirmed through XRD, FTIR, and TEM analyses. Electrochemical characterization revealed that the NiWO₄ NP-modified GCE exhibited a significantly reduced charge transfer resistance (R_ct = 165.25 Ω cm²) compared with the bare GCE, along with an enhanced electrochemically active surface area (0.126 cm²vs. 0.092 cm²) in the [Fe(CN)₆]^3-/4- (5 mM)/KCl (0.1 M) redox system. Amperometric i-t studies demonstrated a broad linear detection range from 0.001 to 719 µM with a very low detection limit of 0.47 nM. Furthermore, the NiWO₄/RDE sensor displayed excellent selectivity, operational stability, reproducibility, and long-term stability. Real-sample analysis confirmed its practical applicability, with DPM recoveries ranging from 95.54 ± 0.01% to 99.2 ± 0.37% in yogurt and chicken samples. This work introduces a CTAB-mediated strategy that enhances the biosensing capability of NiWO₄ nanoparticles through improved electrochemical properties, offering a promising and real-sample-compatible platform for effective dopamine sensing.