累積平均BMIと認知機能低下の関連:24年間のコホート研究
Qianhui Xu1, Meng Hsuan Sung2, Zhuo Chen3,4
1Graduate School of Art and Science, New York University, New York, NY, 10012, USA.
Journal of neurology
|February 27, 2026
まとめ
累積平均ボディマス指数(caBMI)が高いと、認知機能低下が加速することが関連付けられています。この影響は8年後に最も強く現れ、脳の健康のための長期的な体重管理の重要性を強調しています。
科学分野:
- 神経科学
- 公衆衛生
- 老年医学
背景:
- 高いボディマス指数(BMI)は、認知機能の低下と関連しています。
- 累積平均BMI(caBMI)の長期的な影響に関する研究は限られています。
- caBMIの影響を理解することは、認知機能の健康戦略にとって重要です。
研究 の 目的:
- caBMIと認知機能低下との関連を調査すること。
- caBMIが認知機能低下を最も強く予測する重要な時間的範囲を特定すること。
- 認知機能を維持するための長期的な体重管理戦略に情報を提供すること。
主な方法:
- 健康と退職調査(1996-2020年)のデータを利用しました。
- 記憶力と実行機能の複合スコアを使用して、全体的な認知機能を評価しました。
- 追跡期間中の平均BMIとしてcaBMIを計算し、分析には線形混合モデルを使用しました。
主要な成果:
- caBMIの100単位増加は、全体的な認知機能、実行機能、記憶力における認知機能低下の加速と相関していました。
- caBMIと認知機能低下との間の最も強い関連は、8年目に見られました。
- 高齢者(65歳以上)は、若年成人よりもcaBMIと認知機能低下との関連がより大きいことが示されました。
結論:
- 累積平均BMIは、時間の経過とともに認知機能低下と有意に関連しています。
- 認知機能の維持には、体重管理と一貫したBMIモニタリングが不可欠です。
- この結果は、神経学的幸福のための長期的な体重傾向に対処することの重要性を強調しています。
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