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Updated: Feb 28, 2026

CT-guided Preoperative Localization of Pulmonary Nodules Using a Glucose Test and Tissue Adhesive

CT-guided Preoperative Localization of Pulmonary Nodules Using a Glucose Test and Tissue Adhesive

Published on: January 30, 2026

良性対悪性肺結節：胸膜癒着のリスクと予測因子

Jiaheng Zhang¹, Keyue Qiu¹, Hang Chen¹

¹Department of Thoracic Surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, China.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

|February 27, 2026

要旨

Background:

Differentiating pulmonary nodule pathology is challenging. Pleural adhesions complicate surgery, potentially relating to nodule characteristics. This study explores the correlation between nodule pathology and pleural adhesions.

Methods:

A single-center retrospective study included 539 patients with surgically resected pulmonary nodules. Pleural adhesions were graded, and univariate/multivariate analyses identified influencing factors. Prediction models and a nomogram were constructed.

Results:

Benign nodules had a higher adhesion rate (54.8% vs. 17.6%) but mostly localized adhesions; malignant nodules had more extensive adhesions (7.2% vs. 1.6%). Age, benign nodules, and preoperative fibrinogen were independent factors. Fibrinogen alone (AUC = 0.907) and the combined model (AUC = 0.894) showed excellent predictive performance.

Conclusion:

Benign nodules are more associated with pleural adhesions, while malignant ones cause more extensive adhesions. Age and fibrinogen are key risk factors. Fibrinogen is a reliable biomarker, and the nomogram aids individualized preoperative risk assessment.

キーワード:

胸膜癒着肺結節後ろ向き研究リスク因子胸部外科学

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Use of Electromagnetic Navigational Transthoracic Needle Aspiration E-TTNA for Sampling of Lung Nodules

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Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

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