慢性感染症におけるバイオフィルムのパラダイム：到達点ではなく、新たな出発点

Thomas Bjarnsholt¹, Claus Lex², Phil Stewart³

¹Costerton Biofilm Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Microbiology, Copenhagen University Hospital, Copenhagen, Denmark.

|February 27, 2026

Abstract:

Biofilms have profoundly shaped our understanding of chronic infection, yet their explanatory reach is limited. This commentary argues that chronicity emerges from a host-pathogen partnership, where host-derived structural, metabolic, immune, and systemic constraints define persistence, tolerance, and treatment responses beyond microbial architecture alone.

キーワード:

慢性感染症バイオフィルム宿主-病原体相互作用感染持続性治療抵抗性

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