心筋梗塞後の好中球の不均一性

Cardiovascular diseases, including myocardial infarction, are the leading cause of death worldwide. Neutrophils have emerged as actors in non-infectious pathologies and play major roles in cardiovascular diseases: after myocardial infarction, neutrophils are the first cell recruited to the ischemic heart and display multifaceted roles in orchestrating post myocardial infarction tissue healing and repair. Interestingly, recent studies described a high heterogeneity in neutrophils during this process.

At steady state, neutrophils present diversity during their development in hematopoietic organs, and in the circulation after reaching maturity. Inflammatory environments elicit neutrophil reprogramming and further complexify neutrophil heterogeneity, especially leading to the emergence of tissue-specific populations including SiglecF+ neutrophils. Neutrophils play beneficial and deleterious roles after myocardial infarction: they originate from diverse sources including the bone marrow, the spleen and from the marginated neutrophil pool, and display a time-dependent appearance of heterogeneous profile within the cardiac tissue.

Neutrophil heterogeneity in the cardiac tissue could explain the contrasting roles ascribed to neutrophils after myocardial infarction. Increased knowledge in neutrophil diversity will enable the identification of specific targets to improve cardiac healing processes.