血栓閉塞性末梢挿入中心静脈カテーテルの機能回復における技術の比較研究：インビトロモデル研究

To compare the efficacy, safety, and operational efficiency of the intermittent negative-pressure guidewire technique and the stay-locking technique in restoring the function of thrombotically occluded peripherally inserted central catheters (PICCs).

An in vitro thrombotically occluded PICC model was created using 110 catheters, with successful occlusion established in 90. The experimental group comprised 43 models treated with the intermittent negative-pressure guidewire technique, while the control group included 45 models treated using the stay-locking technique. Relevant procedural data were collected and analyzed statistically.

The success rate was significantly higher in the experimental group (62.79%) compared with the control group (4.44%, P < .0001). There was no significant difference in the incidence of thrombus overflow at the catheter tip between groups (P = .704); however, the length of thrombus overflow was significantly greater in the control group (P = .001). Additionally, successful interventions were associated with significantly shorter operation times and significantly higher-pressure recovery rates (P < .0001 for both comparisons).

In an in vitro model of thrombotically occluded PICCs, the intermittent negative-pressure guidewire technique demonstrated superior efficacy, including shorter operation time and higher success rates, compared with the stay-locking technique. The marked increase in the pressure recovery rate in successful cases indicates the technique's effectiveness in restoring catheter function.