内境界膜フラップ手術後の難治性黄斑円孔に対する点眼療法

Mohammad Z Siddiqui¹, Gaurav K Shah², Kevin J Blinder¹

¹The Retina Institute, St. Louis, Missouri, USA.

Retinal cases & brief reports

|February 27, 2026

要旨

Purpose:

Vitrectomy with an internal limiting membrane (ILM) flap has been used in the repair of macular holes (MH). Topical drops have been attempted for smaller MHs with limited data. This study aims to demonstrate the effectiveness of a topical drop regimen in failing MHs after ILM flap surgery.

Methods:

Review of 3 eyes with open MHs after vitrectomy with ILM flap. Preoperative visual acuity, MH size, tamponade used during surgery, time-to-hole closure, and final visual acuity were collected.

Results:

Average MH size among all eyes was 743.3µm (+ 150.4). At the postoperative visit, the MHs were open. All eyes were started on topical steroid, nonsteroidal, and carbonic anhydrase inhibitor drops twice daily for a mean time of 33 days (+ 11 days). There was successful closure of the MHs with topical therapy in all cases.

Conclusions:

Topical therapy may aid in post-operative MH closure.

キーワード:

内境界膜フラップ黄斑円孔点眼薬

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