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Updated: Jun 3, 2026

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding
09:14

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding

Published on: August 22, 2016

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皮膚老化における細胞外マトリックス変化のin vitroモデリング：静的2Dから3D動的マイクロ生理学的システムまで

Yu Yao1, Zilin Zhang2, Jing Zhang3

  • 1Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100144, Beijing, China.

Microsystems & nanoengineering
|February 27, 2026
PubMed
まとめ

このレビューでは、皮膚老化の研究およびアンチエイジング創薬のためのin vitroモデルを探求します。研究における長所と短所を強調しながら、2Dからスキンオンチップまでのさまざまなモデルについて論じます。

キーワード:
皮膚老化細胞外マトリックスin vitroモデル3D再構築皮膚スキンオンチップアンチエイジング創薬

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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...