栄養摂取は精神疾患の発生と関連している:集団ベースの前向きコホート研究
Tingting Mao1, Yifan Gou1, Lina Qin1
1Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, No. 76 Yan Ta West Road, Xi'an, 710061, People's Republic of China.
European journal of nutrition
|February 28, 2026
まとめ
食事の栄養素摂取は精神的健康に関連している。多価不飽和脂肪酸、タンパク質、食物繊維、炭水化物の摂取量が多いと、うつ病、不安症、自殺のリスクが低下する可能性がある。
科学分野:
- 栄養精神医学
- 疫学
- 精神保健研究
背景:
- 栄養消費と精神的健康障害の関係は、まだ十分に探求されていない。
- 精神的健康に対する食事パターンの影響を調査することは、公衆衛生にとって極めて重要である。
研究 の 目的:
- 特定の栄養素摂取とうつ病、不安症、自殺のリスクとの関連を調べること。
- 精神的健康状態の潜在的な食事バイオマーカーを特定すること。
主な方法:
- 169,776人のUK Biobank参加者の食事データ(Oxford WebQ)と精神疾患の診断(ICD-10)を中央値10.4年間追跡して分析した。
- 栄養素摂取レベルを三群に分類し、Cox比例ハザードモデルを用いて分析した。
- 性別、ボディマス指数、Townsend剥奪指数に基づくサブグループ分析を実施した。
主要な成果:
- 多価不飽和脂肪酸、脂肪、タンパク質、食物繊維、炭水化物の摂取と精神疾患との間に有意な関連が見られた。
- n-3脂肪酸とうつ病、植物性タンパク質と不安症、脂肪と自殺との間には逆の関連が観察された。
- これらの関連は主に女性で有意であり、n-3脂肪酸の摂取量が多いほど、このグループでのうつ病のリスクが低いことが示された。
結論:
- 食事の栄養素摂取は、うつ病、不安症、自殺のリスクと有意に関連している。
- 本研究の結果は、栄養素摂取が精神的健康戦略における予測因子または予防因子として機能する可能性を示唆している。
- 精神的健康に対する特定の栄養素とその影響に関するさらなる研究が求められる。
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