毒性学における人工知能革命:臨床的精度、世界的公平性、および2030年のロードマップ
1Universitat Rovira i Virgili, Laboratory of Toxicology and Environmental Health, School of Medicine, San Llorens 21, Reus, Catalonia 43201, Spain.
Toxicology letters
|February 28, 2026
まとめ
人工知能(AI)は、より迅速かつ正確な方法で毒性学に革命をもたらしています。バイアスや解釈可能性のような課題は、毒性学における責任あるAI統合のためのロードマップを必要とします。
科学分野:
- 毒性学
- 人工知能
- 計算毒性学
背景:
- 人工知能(AI)は、毒性学を含む様々な科学分野でますます応用されています。
- AIは、毒性学における診断、治療、研究、教育の向上の可能性を提供します。
- 現在のAIアプリケーションは、臨床毒性学、予測モデリング、ファーマコビジランス、およびトレーニングに及びます。
研究 の 目的:
- 毒性学におけるAI応用の最近の進歩をレビューすること。
- 深層学習、強化学習、生成AIなどの毒性学におけるイノベーションを強調すること。
- 責任あるAI採用のための課題を特定し、ロードマップを提案すること。
主な方法:
- 毒性学のためのAIの最近の進歩を統合する文献レビュー。
- 臨床毒性学、予測モデリング、ファーマコビジランス、および教育におけるAIアプリケーションの分析。
- AI採用を妨げる主要な制限と課題の特定。
主要な成果:
- AIのイノベーションには、診断のための深層学習、投薬のための強化学習、シミュレーションのための生成AIが含まれます。
- アルゴリズムのバイアス、限定的な解釈可能性、および検証の課題は、臨床的および規制上の採用を妨げます。
- 世界的なデジタル格差は、AIの実装にさらなる制約をもたらします。
結論:
- 毒性学における責任あるAI統合には、バイアス、解釈可能性、および検証に対処する必要があります。
- 「ToxAI Pact」は、調和された標準とインフラストラクチャのための2030年のロードマップを提供します。
- 公平性、説明可能性、およびガバナンスを埋め込むことにより、AIはグローバル毒性学の基盤インフラストラクチャとして確立されます。
関連する概念動画
Issues And Trends In Healthcare Delivery System
6.3K
The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
6.3K
Drug Control Governance: Regulatory Bodies and Their Impact
615
Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with...
615
Microorganisms in Medicine and Therapeutics
1.3K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.3K
Global Regulatory Systems
789
Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
789
Synthetic Biology
5.7K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
Golden rice
Golden rice is a genetically modified...
5.7K
Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions
58
PK–PD modeling has significantly influenced FDA regulatory decisions, particularly drug approval, dosage optimization, and labeling. These models integrate pharmacokinetics (PK) and pharmacodynamics (PD) to predict drug behavior and effects, aiding in optimizing dosing regimens and enhancing the probability of clinical trial success.One notable example is Nesiritide (Natrecor®), a recombinant human brain natriuretic peptide for treating acute decompensated congestive heart failure...
58
