スパーク病性パーキンソン病における自律神経障害進行の遅延予測因子としての脳脊髄液LRRK2

The pathophysiological biomarkers underlying the progression of autonomic dysfunction in Parkinson's disease (PD) are not fully understood. We conducted a cohort analysis of 116 sporadic PD patients to determine whether CSF concentrations of total LRRK2 protein and its phosphorylated substrate p-Rab10 predict the trajectories of SCOPA-AUT scores over five years. CSF LRRK2 and p-Rab10 were similarly elevated in sporadic PD and LRRK2 mutation carriers compared with controls. In linear mixed-effects models, higher baseline CSF LRRK2 levels were associated with attenuated annual SCOPA-AUT progression (Ln LRRK2 * time interaction: β = -0.714 points/year; p = 0.003), whereas the interaction between Ln p-Rab10 and time was not significant. These findings indicate that CSF LRRK2 may serve as a biomarker for the progression of autonomic dysfunction in sporadic PD.