動物研究における組成管理を通じた実験的厳密性の実現：精製食の活用
Fangtao Chi1, Shixun Han1, Ömer H Yilmaz2
1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Cell metabolism
|February 28, 2026
Abstract:
Purified diets offer compositionally defined platforms that improve causal inference in nutrition studies. When aligned with the biological question, they enable targeted nutrient loss- and gain-of-function experiments, systematic lipid-source swaps, and the discovery of diet-microbiome-drug interactions. We recommend complementary validation in grain-based chow or human-relevant diets to maximize translational relevance.
