単回および複数食品経口免疫療法中の好酸球性食道炎の発生率

Over the past decade, significant progress has occurred with utilizing oral immunotherapy (OIT) in the treatment of IgE-mediated food allergies. Eosinophilic esophagitis (EoE) is a known potential adverse effect of OIT.

The primary objective was to assess the rate of a new diagnosis of EoE. Secondary objectives included evaluating the development of EoE among patients undergoing single versus multi-food OIT, assessing the symptoms among those who developed EoE, as well as, identifying which foods were associated with the development of EoE.

A retrospective review of patients undergoing OIT from 2018 through May 2024 at the Children's Hospital of Philadelphia was performed.

This study identified 1200 children who have undergone or were undergoing OIT. A total of 51 patients underwent evaluation for suspected EoE and 8 were ultimately diagnosed with EoE. No difference in EoE development was observed between those on single versus multi-food OIT. Peanut and egg were the most common foods for which patients experienced gastrointestinal symptoms. No patients on milk, wheat or soy OIT were found to have EoE.

In a cohort of 1200 children on OIT at a tertiary pediatric hospital with robust OIT and EoE programs, the rate of newly diagnosed EoE during OIT was found to be 0.7%, which is lower than prior studies. This study demonstrated regular screening before and during OIT is associated with a reduced rate of EoE. Clinicians should be mindful that patients undergoing OIT with more numerous, severe and persistent gastrointestinal symptoms may be at higher risk for EoE.