関連する実験動画

Updated: Mar 3, 2026

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

エリートコントローラーにおけるHIVリザーバーの状況

Cristina Moral-Turón¹, María Antequera-Martínez, Ezequiel Ruiz-Mateos

¹Institute of Biomedicine of Seville, IBiS/Virgen Del Rocío University Hospital/CSIC/University of Seville, Clinical Unit of Infectious Diseases, Microbiology and Parasitology, Seville, Spain.

Current opinion in HIV and AIDS

|March 2, 2026

要旨

Purpose Of Review:

In this review, we intend to define the main characteristics of the elite controller reservoir, exploring into its heterogeneity, which goes hand in hand with the different progression phenotypes within elite controllers.

Recent Findings:

Show that the viral reservoir measured by high-resolution techniques in elite controllers is heterogeneous, exhibiting distinct characteristics in elite controllers who ultimately lose control compared to those with persistent viral remission. Among the latter, we find exceptional individuals with a reservoir consistent with a phenomenon of "block and lock," and even with a potential sterilizing cure.

Summary:

The HIV-1 reservoir in elite controllers is heterogeneous; discriminating the distinct characteristics of reservoir profiles in elite controllers can provide important clues about how to achieve an HIV cure.

キーワード:

HIV治癒エリートコントローラー完全かつ欠陥のあるプロウイルスリザーバー

さらに関連する動画

Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment

Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment

Published on: June 23, 2019

Amplification of Near Full-length HIV-1 Proviruses for Next-Generation Sequencing

Amplification of Near Full-length HIV-1 Proviruses for Next-Generation Sequencing

Published on: October 16, 2018

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