黄熱ワクチン接種,鳥類白血病ウイルス,ヒトにおけるがんリスク
まとめ
この研究では,第二次世界大戦中の黄熱予防接種と退役軍人のがんとの間に関連性がないことが判明しました. 鳥類白血病・肉腫ウイルスを含む可能性のあるワクチンは,白血病やリンパ腫の発生率の増加と相関していない.
科学分野:
- 腫瘍学 腫瘍学
- 免疫学 免疫学とは
- エピデミオロジー エピデミオロジー
背景:
- 第二次世界大戦の退役軍人は黄熱予防接種を受けました.
- このワクチンは,鶏の胚を用いて製造され,受給者に鳥の白血病・肉腫ウイルスに潜在的に感染させる可能性がある.
- ワクチンのウイルス汚染物質の潜在的な腫瘍学的影響に関する懸念があります.
研究 の 目的:
- 第二次世界大戦中の黄熱ワクチン接種と,後に退役軍人のがん発症との関連を調査する.
- ワクチン接種による鳥類白血病・肉腫ウイルスへの曝露が癌のリスクを増やすかどうかを判断する.
主な方法:
- ケース・コントロール・スタディ・デザインが採用されました.
- 1950年から1954年,または1959年から1963年の間に癌で亡くなった2659人の退役軍人を,マッチした対照群と比較した.
- 第二次世界大戦中の黄熱予防接種の頻度に関するデータが収集され,分析されました.
主要な成果:
- 黄熱ワクチン接種と白血病の発症との間に統計的に有意な関連性は見つかりませんでした.
- 黄熱ワクチン接種とリンパ腫との間に有意な関連は観察されなかった.
- この研究では,研究された退役軍人の間で黄熱予防接種と他の形態の癌との間には相関関係がないことが判明しました.
結論:
- 第二次世界大戦中の黄熱予防接種は,退役軍人の白血病,リンパ腫,または他の癌を発症するリスクを増加させるようには見えません.
- ワクチンの鳥類白血病-サーコマウイルスの潜在的な存在は,このコホートにおける検出可能な癌発生率の増加に転じませんでした.
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