2つの形態学的に異なる血脳障壁が,シトクロームcが脳脊髄液に侵入するのを防ぐ
Science (New York, N.Y.)
|April 6, 1973
まとめ
細胞染色体cは,血脳バリアがはっきりしているため,脳脊髄液に侵入できません. ピノサイトーシスは,脳壁を越える輸送ではなく,細胞内分解を促進する可能性があります.
科学分野:
- 神経科学は神経科学である.
- 細胞生物学 細胞生物学
- バイオケミストリー バイオケミストリー
背景:
- 血脳障壁 (BBB) は,分子が脳に通過することを制限します.
- 細胞染色体cのような必須タンパク質の輸送機構を理解することは,神経生物学にとって極めて重要です.
研究 の 目的:
- 血液-脳インターフェースの間のシトクロームcの輸送およびバリア特性を調査する.
- 細胞染色体cが脳パレンキマおよび脳脊髄液に侵入することを制限するエンドセリアおよび上皮壁の役割を解明する.
主な方法:
- モデルシステムでシトクロームcの静脈内注射.
- 顕微鏡を用いた形態学的分析により,シトクロームcの分布を追跡する.
- 細胞の吸収と細胞内処理機構の評価.
主要な成果:
- サイトクロームcは,静脈内注射後,脳脊髄液に吸収されませんでした.
- 毛細血管内皮は,ほとんどの脳領域で障壁として作用し,シトクロームcの拡張を防止しました.
- 冠状腺では,シトクロームcは細胞外空間に入ったが,膀に内化され,リソソームによって分解され,上皮細胞に運ばれなかった.
結論:
- サイトクロームcには少なくとも2つの異なる血脳障壁が存在する.
- ピノサイトーシスは,シトクロームcの細胞間輸送ではなく,細胞内分解のメカニズムであるようです.
- これらの発見は,脳の血管系と障壁の選択的浸透性についての洞察を提供します.
関連する概念動画
00:49The Blood-brain Barrier
Overview
01:23Transcellular Transport of Solutes
Transcellular transport of solutes is the movement of substances like monosaccharides and amino acids through polarized cells. This transport mechanism is primarily seen in epithelial and endothelial cells aided by membrane transport proteins such as channels and transporters. The tight junctions between these cells confine the membrane proteins to the two sides of the cell. The epithelial cells have distinct apical and basolateral domains. In contrast, the endothelial cells show the luminal...
01:18Anatomy of the Brain: Ventricles
There are hollow fluid-filled cavities known as ventricles deep inside the human brain. There are two lateral ventricles, one in each cerebral hemisphere, and each has three different projections — the anterior, inferior, and posterior horns visible from the lateral side. A thin membrane called the septum pellucidum separates the two lateral ventricles. The slender third ventricle in the diencephalon is connected to each lateral ventricle via a channel called the interventricular foramen. The...
01:21Cerebrospinal Fluid
Cerebrospinal fluid (CSF) is a colorless liquid that flows around the brain and the spinal cord, playing a vital role in the protection, support, and overall function of the central nervous system (CNS). CSF production, circulation, and absorption are tightly regulated processes essential for the brain and spinal cord to function properly.
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain.
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain.
01:25Physiological Barriers
Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
01:22Cerebral Edema ll: Pathophysiology
Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...