最下位メタゾア属属における免疫能力:スポンジにおける移植免疫

W H Hildemann, I S Johnson, P L Jokiel

Science (New York, N.Y.)

|April 27, 1979

まとめ

海洋スポンジの移植では,細胞表面マーカーにより互換性のあるイソ移植と不互換性のあるアロ移植が見られます. これは,Callyspongia diffusa.の特定の移植免疫と記憶を示しています.

科学分野:

マリン・バイオロジーの海洋生物学
免疫学免疫学とは
遺伝学遺伝学とは

背景:

細胞表面マーカーは,免疫認識において重要な役割を果たします.
移植の互換性は種によって大きく異なります.
無脊椎動物におけるヒストコンパティビリティを理解することは,免疫進化の洞察を提供します.

研究の目的:

海洋スポンジCallyspongia diffusa.で組織移植の互換性を調査する.
カリスポンジア・ディフュサの異なるクローン間の組織適合性の障壁の性質を特徴づける.
スポンジ移植拒絶における特定の免疫記憶の存在を決定する.

主な方法:

カリスポンジア・ディフュサ (Callyspongia diffusa) のイソ移植 (遺伝的に同一) とアロ移植 (遺伝的に異なった) を用いた移植実験.
移植の融合と拒絶の観察.
ファーストセット,セカンドセット,サードパーティの移植に対する反応時間の分析.
拒絶中の細胞毒性シケラの評価.

主要な成果:

カリスポンジア・ディフュサ (Callyspongia diffusa) のイソ移植は,相容れる融合を示した.
アロ移植は常に互換性がなく,強烈な組織適合性の障壁を示した.
ヒストコンパティビリティの障壁は,インタークローナル組み合わせによって強度が異なる.
重要な細胞毒性作用による早期拒絶は,アロ移植の典型的であった.
移植拒絶パターンは,メモリコンポーネントを持つ特定の,差別的な移植免疫を示した.

結論:

カリスポンジア・ディフューザは,自己組織と非自己組織を区別できる複雑な免疫システムを備えています.
細胞表面マーカーの観察されたポリモルフィズムが,組織相容性障壁の基礎となっている可能性が高い.
特定の免疫記憶の存在は,スポンジの適応免疫能力を示唆しています.

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