腎臓梗塞における血清乳酸デヒドロゲンアース濃度の上昇
関連する実験動画
Updated: Oct 30, 2026
09:09
Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice
Published on: August 9, 2013
JAMA
|July 20, 1979
まとめ
血清乳酸脱水素酶 (LDH) の有意な増加は,SGOTまたはアルカリリンフォスファターゼの実質的な上昇なしに,腎臓梗塞を示唆します. この発見は,他の原因が排除されているときに腎臓の問題を診断するのに役立ちます.
科学分野:
- ネフロロジーはネフロロジーを用います.
- 診断医学 診断医学
- バイオケミストリー バイオケミストリー
背景:
- 血清酵素レベルは,臓器損傷の診断において極めて重要です.
- 腎臓梗塞の診断は,特定のバイオマーカーを必要とするため,難しいことがあります.
- 乳酸脱水素酶 (LDH) の上昇は,組織損傷の一般的な指標です.
研究 の 目的:
- 腎不全における単離された高血清LDHの診断的意義を評価する.
- LDH上昇を引き起こす他の状態から腎臓梗塞を区別するために.
主な方法:
- 腎臓梗塞が確認された5人の患者のケースシリーズ分析.
- LDH,SGOT,アルカリリンフォスファターゼを含む血清酵素濃度の分析.
- 患者の病歴と腎臓梗塞の病因因子のレビュー.
主要な成果:
- 腎臓梗塞の患者5人は,血清LDH濃度が著しく上昇したことを示した.
- これらの上昇は,SGOTとアルカリリンフォスファタゼの増加に不釣り合いでした.
- 血液溶解や心筋梗塞などの単一のLDH上昇の一般的な原因は除外されました.
結論:
- SGOTとアルカリリンフォスファターゼの変化が最小で,血清LDHが顕著に上昇することは,腎臓梗塞の重要な診断指標です.
- この酵素パターンは,腎臓梗塞を特定するのに役立ちます,特に心房不律や大動脈動脈瘤などの状態と関連する場合です.
関連する概念動画
01:28Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:24Serum Studies: Renal Function Tests
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
01:22Acute Kidney Injury I: Introduction
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...