関連する実験動画

Updated: May 5, 2026

In vitro Synthesis of Native, Fibrous Long Spacing and Segmental Long Spacing Collagen
07:54

In vitro Synthesis of Native, Fibrous Long Spacing and Segmental Long Spacing Collagen

Published on: September 20, 2012

14.3K

溶解性I型コラーゲン分子の結合が,線維芽細胞のプラズマ膜に結合する

B Goldberg

    Cell
    |February 1, 1979
    PubMed
    まとめ

    溶解性I型コラーゲンは,上皮細胞ではなく,繊維芽細胞に特異的に結合する. この結合は可逆性があり,飽和性があり,線維芽細胞表面の高親近性部位によって媒介され,細胞-マトリックス相互作用における役割を示唆しています.

    さらに関連する動画

    An Improved Method for the Preparation of Type I Collagen From Skin05:17

    An Improved Method for the Preparation of Type I Collagen From Skin

    Published on: January 22, 2014

    22.3K
    Evaluation of Keratinocyte Proliferation on Two- and Three-dimensional Type I Collagen Substrates08:19

    Evaluation of Keratinocyte Proliferation on Two- and Three-dimensional Type I Collagen Substrates

    Published on: April 22, 2019

    9.7K

    関連する概念動画

    Introduction to Fibroblasts01:09

    Introduction to Fibroblasts

    Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
    3.9K
    Fibril-associated Collagen01:11

    Fibril-associated Collagen

    Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
    For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
    2.7K
    Fibronectins Connect Cells with ECM01:25

    Fibronectins Connect Cells with ECM

    Fibronectin is an adhesive glycoprotein present in the extracellular matrix of embryogenic and adult tissue. These molecules primarily aid in regulating cell motility and attachment. A fibronectin molecule is composed of two identical polypeptide chains attached to each other by a pair of disulfide bonds at the C-terminal.
    Both proteoglycans and collagen are attached to fibronectin proteins, which, in turn, are attached to integrin proteins. These integrin proteins interact with transmembrane...
    2.9K
    Type IV Collagen of Basal Lamina01:05

    Type IV Collagen of Basal Lamina

    Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
    A type IV collagen molecule has six alpha chains which can...
    2.6K
    Overview of Cell-Matrix Interactions01:24

    Overview of Cell-Matrix Interactions

    The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
    8.0K
    Intracellular Signaling Affects Focal Adhesions01:17

    Intracellular Signaling Affects Focal Adhesions

    Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
    Some...
    2.8K