閉経期のフラッシュ:神経内分泌のリンクとパルス性のルテニニズホルモン分泌の脈動性
Science (New York, N.Y.)
|August 24, 1979
まとめ
更年期中の熱帯は,下垂体と関連しています.
科学分野:
- 神経内分泌学の神経内分泌学
- 生殖医学は,生殖器医学である.
- 閉経研究 閉経研究
背景:
- 閉経期の熱帯は,一般的な,破壊的な症状です.
- ホットフラッシュの基礎となる生理学的トリガーは,まだ完全に理解されていません.
研究 の 目的:
- 閉経期の熱帯に先立つ神経内分泌現象を調査する.
- ルテイン化ホルモンの放出とホットフラッシュの発症の関係を探求する.
主な方法:
- 閉経期の熱中症の間,ホルモンおよび生理学的パラメータをモニタリングする観察研究.
- ルテイン化ホルモン,カテキアミン,プロラクチン濃度の測定.
主要な成果:
- 更年期フラッシュエピソードは一貫して,下垂体から脈動性ルテイン化ホルモン (LH) の放出の開始と一致しました.
- これらのエピソードの間,循環中のカテキオラミンまたはプロラクチン濃度の有意な変化は観察されなかった.
結論:
- この発見は,脈動性LH分泌の神経内分泌制御と更年期熱帯の発生との間の直接的な関連性を示唆しています.
- ルテイン化ホルモン放出因子の下垂体調節は,ホットフラッシュのエピソードを誘発する役割を果たす可能性があります.
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