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Updated: Sep 16, 2026

Characterizing the Composition of Molecular Motors on Moving Axonal Cargo Using "Cargo Mapping" Analysis
11:09

Characterizing the Composition of Molecular Motors on Moving Axonal Cargo Using "Cargo Mapping" Analysis

Published on: October 30, 2014

軸索輸送のメカニズム:カルシウムイオンの役割が提案されています

R Hammerschlag, A R Dravid, A Y Chiu

    Science (New York, N.Y.)
    |April 18, 1975
    PubMed
    まとめ

    カルシウムイオンは,神経細胞内の軸索輸送とタンパク質結合の開始に不可欠です. 神経細胞体からカルシウムを取り除くと,タンパク質の輸送が著しく損なわれ,その重要な役割が強調されます.

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    Expanding the Toolkit for In Vivo Imaging of Axonal Transport09:24

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    関連する概念動画

    Action Potentials01:41

    Action Potentials

    Overview
    The Movement of Organelles and Vesicles01:43

    The Movement of Organelles and Vesicles

    In eukaryotic cells,  cytoskeletal filaments such as actin, microtubules, and intermediate filaments form a mesh-like cytoskeletal network. These filaments serve as tracks for transporting cellular cargo. Specialized motor proteins use the chemical energy stored in adenosine triphosphate (ATP) for this transport. During interphase, microtubules are polarized, with the plus-end towards the cell periphery and the minus-end towards the cell center. Two microtubule-associated motor proteins,...
    The Role of Ion Channels in Neuronal Computation01:19

    The Role of Ion Channels in Neuronal Computation

    A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
    Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential.
    Mechanism of Ciliary Motion01:05

    Mechanism of Ciliary Motion

    The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
    The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
    Neurons: The Axon01:21

    Neurons: The Axon

    Axons are long, cytoplasmic processes of nerve cells capable of propagating electrical impulses known as action potentials. The cytoplasm or axoplasm of an axon contains neurofibrils, neurotubules, small vesicles, lysosomes, mitochondria, and various enzymes, all encased within the axolemma, the plasma membrane of the axon.
    The axon attaches to the cell body at a cone-shaped elevation called the axon hillock. The initial part of the axon, closest to the hillock, is known as the initial segment.
    Action Potential01:14

    Action Potential

    Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
    Membrane potential in neurons
    Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...