エッセンシャル高血圧に対するチアジドの長時間治療中に全身および血清のカリウム
Lancet (London, England)
|April 5, 1975
まとめ
この研究では,ベンドロフルアジドを服用している軽度の高血圧患者は血清カリウム濃度の低下を示したが,全体カリウム損失は有意ではなかった. 通常のカリウムサプリメントは,この治療には必要ないかもしれません.
科学分野:
- 心臓病学 心臓病学
- 薬理学 薬理学とは
背景:
- シアジド利尿剤は,通常,高血圧に対して処方されます.
- シアジド利尿剤の潜在的な副作用は,低血量症 (低血清カリウム) である.
- 高血圧に対するチアジド療法中のカリウム損失の臨床的意義については,さらなる調査が必要である.
研究 の 目的:
- ベンドロフルアジドが血清カリウムと全体カリウム (T.B.K.) に与える影響を評価する. 軽度のエッセンシャル高血圧の患者に投与する.
- ティアジド利尿剤で合併症のないエッセンシャル高血圧を治療する際に,定期的なカリウム補給が必要かどうかを判断する.
主な方法:
- 血清カリウムとT.B.K.の連続測定 1年以上にわたって.
- 軽度のエッセンシャル高血圧の18人の患者は,カリウムサプリメントなしで1日10mgのベンドロフルアジドを投与されました.
- 血圧と副作用をモニターした.
主要な成果:
- 12ヶ月後,平均血清カリウム濃度の有意な低下が観察されました.
- T.B.K.K.の有意な減少はありませんでした. 研究期間中に発見されました.
- ダイアストリック血圧の有意な低下が認められ,明らかな副作用はありませんでした.
結論:
- 定期的なカリウム補給は,シアジド利尿剤で治療されている合併症のないエッセンシャル高血圧の患者にとって不可欠ではないかもしれません.
- 血清カリウムが減少した一方で,T.B.K.は減少した. 安定したままであり,臨床的に有意なカリウム枯渇の欠如を示唆しています.
- ベンドロフルアジドは,この患者群で血圧を効果的に低下させました.
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