カルシウム吸収とカルシウム結合タンパク質合成:ソランウムマラコキシロンはストロンチウム阻害を逆転させます
まとめ
ストロンチウムが多いダイエットは,ビタミンDの活性化を阻害することによって,カルシウム吸収を阻害します. 植物Solanum malacoxylonは,活性ビタミンDを模倣し,カルシウムの吸収を助け,これに対抗する因子を含んでいます.
科学分野:
- 栄養科学とは,栄養科学である.
- バイオケミストリー バイオケミストリー
- ファルマコグノシは,薬理学的な知識である.
背景:
- 高濃度のストロンチウム摂取は,カルシウム吸収を阻害する.
- ストロンチウムは,ビタミンDの代謝,特に25-ヒドロキシコレカルシフェロールの1,25-二ヒドロキシコレカルシフェロールへの変換を妨げます.
- ビタミンDの活性形態である1,25-二酸化水素コレカルシフェロールは,腸内カルシウム吸収に不可欠です.
研究 の 目的:
- ストロンチウム誘発によるカルシウム吸収の阻害に対するSolanum malacoxylonの効果を調査する.
- Solanum malacoxylonに,ストロンチウムのビタミンD代謝に対する負の影響を克服できる因子が含まれているかどうかを特定するために.
- この因子が1,25-dihydroxycholecalciferolの作用を模倣するかどうかを判断する.
主な方法:
- 安定したストロンチウムの濃度が高い食事の管理.
- ストロンチウムを含有するダイエットを,南米の植物Solanum malacoxylonで補足する.
- カルシウム吸収とビタミンDの代謝への影響を評価する.
主要な成果:
- 食中のストロンチウムは,カルシウム吸収と腸内カルシウム結合タンパク質合成を著しく抑制しました.
- ストロンチウムを含むダイエットにSolanum malacoxylonを加えると,これらの抑制効果は相殺されました.
- これは,Solanum malacoxylonが1,25-dihydroxycholecalciferolの作用を模倣できる因子を含んでいることを示唆しています.
結論:
- Solanum malacoxylonは,高量のストロンチウムがカルシウム代謝に与える悪影響を軽減する因子を持っています.
- この植物学的要因は,1,25-二酸化水素コレコレカルシフェロールの作用を効果的に代替または真似します.
- これは,このようなビタミンDを模倣する因子の植物源からの最初の識別を表しています.
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