まとめ
猿からの特定のアデノウイルスは,ハムスターの腫瘍を引き起こす可能性があります. サーコピテクスのサルから採取された特定のアデノウイルスは,高い腫瘍発生性を示し,ワクチン接種したハムスターにリンパ腫を急速に誘発した.
科学分野:
- ウイルス学 ウイルス学 ウイルス学
- 腫瘍学 腫瘍学
- 霊長類のアデノウイルス
背景:
- アデノウイルスは,多様な宿主を持つ一般的なウイルスです.
- いくつかのアデノウイルスは,実験動物で腫瘍を引き起こすことが知られている.
- 非ヒトの霊長類からのアデノウイルスによる腫瘍発生の可能性については,さらなる調査が必要である.
研究 の 目的:
- rhesus,Cynomolgus,Cercopithecus類のサルから分離されたアデノウイルスによる腫瘍発生の可能性を調査する.
- 新生ハムスターのこれらのアデノウイルスによって誘発された腫瘍の特徴を明らかにするために.
主な方法:
- 新生ハムスターの皮膚下注は,猿の起源の17種類のアデノウイルスによるものです.
- 腫瘍のモニタリング,特徴付け (組織病理学,クロスコンプリメント固定テスト).
主要な成果:
- アデノウイルス17種のうち5種は,ワクチン接種後42日から280日間のハムスターで腫瘍,主にリンパ腫を誘発した.
- 腫瘍特異性は,クロスコンプリメント固定試験によって確認されました.
- サーコピテクスの猿からのアデノウイルスは高度に腫瘍原性であり,30〜40日以内に,接種したハムスターの23匹すべてに腫瘍を引き起こしました.
結論:
- rhesus と cynomolgus 類人猿からのアデノウイルスは,ハムスターにおいて腫瘍発生的可能性を秘めている.
- サーコピテクスのサルから特定されたアデノウイルスは,重要な腫瘍発生性を示し,リンパ腫を急速に誘発します.
- これらの発見は,霊長類のアデノウイルスの腫瘍発生能力の研究の重要性を強調しています.
さらに関連する動画
13:36Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches
Published on: May 6, 2015
06:25Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining
Published on: December 23, 2016
関連する概念動画
Viral Mutations
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material for adaptive...
Mechanisms of Retrovirus-induced Cancers
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Mechanisms of Retrovirus-induced Cancers
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Mutagenicity and Carcinogenicity
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
