25-ヒドロキシコレカリフェロールと近接骨の骨折
Lancet (London, England)
|August 16, 1975
まとめ
この研究では,プラズマの25-ヒドロキシコレカルシフェロール濃度が,股関節骨折患者と対照群で類似していたことが判明しました. 高齢のデンマーク人の骨粗鬆症は,食事による摂取量より,ビタミンDの変換が損なわれることから生じる可能性があります.
科学分野:
- エンドクリノロジー エンドクリノロジー
- 整形外科 整形外科 整形外科
- ゲリアトリクス ゲリアトリクス
背景:
- 股関節骨折は高齢者によく見られる.
- ビタミンDの欠乏は,骨の脆弱性につながる潜在的な要因です.
- オステオマラシアは高齢者の集団で観察される.
研究 の 目的:
- 血25-ヒドロキシコレカルシフェロール (25-H.C.C.) を検査する. 近い股関節骨折の患者のレベル.
- 25-H.C.C.との関係を探求する. そして,骨代謝マーカーです.
- デンマークの高齢者の骨粗鬆症の潜在的な原因を評価する.
主な方法:
- 血25-ヒドロキシコレカルシフェロールを測定した67件の連続した近隣股関節骨折症例.
- 患者値と対照群を比較した.
- 25-H.C.C.,プラズマカルシウム,リン,Ca x P産物,およびアルカリ性ファスファターゼの間の相関を分析した.
- ローザーゾーンをX線で調べました.
主要な成果:
- プラズマ25-H.C.C.というものです. 股関節骨折患者における血中濃度は,対照群と異なるものではありませんでした.
- 25-HCCCとの間に有意な相関は見つかりませんでした. そして,カルシウム,リン,Ca x P産物,またはアルカリ性ファスファターゼ.
- オステオマラシアの兆候である緩やかな領域は,最も低い25-H.C.C.を持つ1人の患者だけに存在していました. レベル. レベル.
結論:
- 低血25-ヒドロキシコレカルシフェロルは,この高齢のデンマーク人コホートにおける近親股関節骨折の主な要因ではありません.
- この集団における骨髄症は,25-H.C.C.の腎臓での変換の低下と関連している可能性が高い. 1,25-ジヒドロキシコレカルシフェロールという活性形態によるものではなく,食事によるビタミンDの摂取量が不十分である.
さらに関連する動画
07:12Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
Published on: September 28, 2017
06:47Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
Published on: May 4, 2018
関連する概念動画
Role of Skin in Vitamin D Synthesis
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Essential Minerals for Bone Health
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Hormones and Bone Tissue
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Skeleton and Calcium Homeostasis
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
Role of Vitamins in Maintaining Bone Health
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
