B型肝炎の垂直伝染のメカニズムとしての母乳栄養に対する証拠
Lancet (London, England)
|October 18, 1975
まとめ
授乳は,キャリアの母親から生まれた乳児のB型肝炎ウイルス (HBV) 抗原血症のリスクを増加させない. この研究では,母乳の授乳と乳児におけるHBV感染または抗原血症との関連は見つかりませんでした.
科学分野:
- 肝臓病理学 肝臓病理学
- 小児科は小児科です.
- ウイルス学 ウイルス学 ウイルス学
背景:
- B型肝炎ウイルス (HBV) 感染症は,世界的な健康上の重大な懸念事項です.
- B型肝炎表面抗原 (HBsAg) を携えている母親から生まれた乳児は,垂直感染のリスクが高い.
- キャリア・マザーから赤ん坊に感染するHBV感染における母乳の役割は,公衆衛生上の懸念事項であり続けています.
研究 の 目的:
- 授乳とHBsAg陽性母から生まれた乳児におけるB型肝炎抗原血症の発生との関連を調査する.
- 授乳が新生児のHBV感染率やキャリアステータスに影響するかどうかを判断する.
主な方法:
- 147人の乳児を対象としたフォローアップ研究では,知られたHBsAg媒介母から生まれた乳児を対象とした.
- 乳児は3ヶ月以上で抗原血症 (HBsAgの存在) のモニタリングを行いました.
- 血清サンプルを採取して分析し,母親のHBsAg titre,帯血の状態,兄弟姉妹の罹患率に関するデータと併せて分析した.
主要な成果:
- 哺乳と乳児の抗原血症の発症を関連付ける統計的に有意な証拠は見つかりませんでした.
- HBsAgとアンチ-HBsの発生頻度は,母乳で育った乳児と,母乳で育たない乳児の両方において同様であった.
- 母親のHBsAg titre,帯血陽性,および兄弟姉妹のHBV流行率は,乳児の栄養状態によって異なるものではありませんでした. 検査された母乳のサンプルはすべてHBsAg陰性でした.
結論:
- 母乳の授乳は,B型肝炎ウイルスの感染を媒介母である乳児への重大な危険因子とは考えられない.
- 現在の発見は,HBsAg陽性母親から生まれた乳児の母乳の安全性を支持しています.
- さらなる研究は,他の潜在的な伝播経路と保護措置を探求することができます.
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