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選択的結腸外科手術における予防的口腔抗菌剤. コントロールされた臨床試験です
Lancet (London, England)
|November 22, 1975
まとめ
メトロニダゾールとカナミシンを含む予防抗生物質は,大腸手術患者の大腸細菌と術後の傷口感染症を大幅に減少させた. この効果的な治療法は,有害な副作用を示さなかった.
科学分野:
- 外科感染症予防 手術感染予防
- 結腸直腸外科手術について
- 微生物学 微生物学とは
背景:
- 結腸外科手術は,生息する微生物群による術後傷口感染症のリスクを伴う.
- アナエロビックバクテリアは,大腸の微生物群の重要な成分です.
研究 の 目的:
- 経口メトロニダゾールとカナミシンの予防効果を評価し,大腸の微生物群を減少させる.
- 術後の傷口感染率に対するこの抗菌薬療法の影響を評価する.
主な方法:
- 選択的結腸外科手術を受けた50人の患者を対象とした制御試験.
- 介入グループは,経口メトロニダゾールとカナミシンを受けた.
- 対照群は,食事と機械的な調理剤のみを摂取した.
主要な成果:
- 治療グループでは,有酸素および無酸素の腸内微生物群の有意な減少が見られました.
- 抗生物質を投与された患者では,手術後の傷口感染症の有意な減少が観察されました.
- 1人の対照患者は,バクテロイド菌血症による致死を経験した.
結論:
- 予防的な経口メトロニダゾールとカナミシンは,大腸の微生物群を減少させるのに有効です.
- このレジミンは,大腸手術後の術後の創傷感染症の発生率を大幅に低下させます.
- 研究された予防療法療法は,有毒な副作用を観察することなく,よく耐えた.
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