ゲンタミシンの耐性のあるPseudomonas aeruginosaとSerratia marcescensが一般病院で検出された
Lancet (London, England)
|March 13, 1976
まとめ
Pseudomonas aeruginosaとSerratia marcescensのゲンタミシン耐性の高い割合は,病院における重大な懸念となっている. アミカシンは,耐性菌株に対して有効性を示し,有効な治療選択肢を提供している.
科学分野:
- 医学微生物学 医学微生物学
- 感染症 感染症は感染症です.
- 抗生物質耐性菌は,抗生物質耐性菌として存在します.
背景:
- 病院で得られた一般的な病原体におけるゲンタミシンの耐性症候群は,臨床的な課題として増大しています.
- Pseudomonas aeruginosaとSerratia marcescensは,病院内感染の重要な原因となっている.
研究 の 目的:
- ゲンタミシン耐性菌の発生率をPseudomonas aeruginosaとSerratia marcescensの孤立種で評価する.
- アミカシン,トブラミシン,シソミシンを含む代替抗生物質に対する耐性菌株のインビトロ感受性を評価する.
主な方法:
- ジェンタミシンの耐性を決定するために,標準化されたディスクテストとアガー-希釈方法が使用されました.
- 最低阻害濃度 (MIC) は,臨床単離物について決定されました.
- アミカシン,トブラミシン,シソミシンに対する感受性検査が行われました.
主要な成果:
- Pseudomonas aeruginosaの19.1%とSerratia marcescensの50.0%がゲンタミシン耐性であった.
- 耐性臨床単離物の80%はジェンタミシンのMIC ≥16μg/mlであった.
- アミカシンはジェンタミシン耐性S.marcescens (100%) とPs.marcescens (100%) に対して高い有効性を示しました. エアルーギノザ (79%).
- トブラミシンとシソミシンはジェンタミシンよりも限られた利点を提供しました.
- ほとんどの単離は尿路から発生し,一部の単離は血液培養にも発見されました.
- 耐性菌株は,敏感菌株と同様の毒性を示した.
- 臨床的改善は,アミカシンで治療された17人の患者のうち13人に観察されました.
結論:
- ゲンタミシンの抵抗性の高い頻度は,Ps. aeruginosa と S. marcescens が持続的な問題となっている.
- アミカシンは,ジェンタミシン耐性菌株によって引き起こされる感染症の効果的な治療法です.
- この結果は,病院環境における抗菌剤耐性の継続的な監視と管理の必要性を強調しています.
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