血中のカドミウム濃度は,正常血圧と未治療高血圧のヒトで測定された
Lancet (London, England)
|April 3, 1976
まとめ
この研究では,健康な対照群と比較して高血圧の個体において,血中のカドミウム濃度が著しく高いことが判明しました. 高濃度のカドミウムは,ヒトにおける高血圧に寄与する要因である可能性があります.
科学分野:
- 環境衛生 環境衛生 環境衛生
- 毒理学 毒理学 毒理学
- 心血管疾患 心血管疾患
背景:
- カドミウムへの曝露は,動物モデルにおける高血圧に関連している.
- 以前の研究では,高血圧患者の死後のヒト組織でカドミウムの値が上昇していることが示されました.
研究 の 目的:
- 血液中のカドミウム濃度と,生きているヒトにおける高血圧との関連を調査する.
- 血液中のカドミウム濃度を,正常な高血圧患者と,未治療の高血圧患者との間で比較するために.
主な方法:
- 血液サンプルは,正常なグループと,未治療の高血圧患者のマッチンググループから採取されました.
- 血液中のカドミウム濃度は,標準化された実験室技術を用いて測定されました.
主要な成果:
- 正常な被験者の平均血中カドミウム濃度は3.4 +/- 0.5ng/mlでした.
- 高血圧の被験者は,11.1 +/- 1.5 ng/mlの平均血中カドミウム濃度が著しく高かった.
- 17人の高血圧患者のうち13人が8.0ng/mlの値を超えたが,すべての正常な被験者はこの値を下回った.
結論:
- 生きている高血圧患者は,血中カドミウム濃度が正常血圧患者と比較して顕著に上昇しています.
- これらの発見は,人間の高血圧の発達または悪化におけるカドミウムの潜在的な役割を示唆しています.
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