関連する実験動画
Updated: Jul 13, 2026

05:17
An Improved Method for the Preparation of Type I Collagen From Skin
Published on: January 21, 2014
まとめ
小児性全身性赤血性狼 (SLE) は,他の子供の結合組織疾患よりも予後が悪いもので,早期発症と特定の症状は,より悪い結果を示す. コルチコステロイドを含む改善された治療法は,SLEの子供の生存率を向上させ,罹患率を低下させました.
科学分野:
- 小児リウマト病学について
- 結合組織疾患 結合組織疾患
- 自己免疫疾患 自己免疫疾患
背景:
- システミック・ルプス・エリテマトーサス (SLE),皮膚性筋炎,および軟骨硬化症は,子供に影響を与える重要な自己免疫疾患です.
- 小児性SLEは,成人発症の病気と比較して,一般的により悪い予後を持つユニークな課題を提示します.
研究 の 目的:
- SLE,皮膚炎,または軟骨硬化症と診断された子供の臨床的特徴,予後,および治療結果を遡及的に分析する.
- 小児性SLEにおける死亡率と罹患率に関連する要因を特定する.
主な方法:
- SLE (39),皮膚筋炎 (25),または硬化症 (7).
- 疾患の発症,臨床的表れ,治療レジメン,患者のアウトカムに関する分析.
主要な成果:
- SLEを患っている子どもは,皮膚性筋炎または硬肌症の患者よりも重症度が高く,予後が悪いことが示され,成人SLE患者よりも悪化しました.
- 発症の早い年齢,胃腸出血,腎臓,心臓の異常は,小児性SLEの死亡率の増加と関連していました.
- ホルモンの影響が役割を果たす可能性があり,思春期近くのSLEのピーク発生が示唆しています.
- 治療の進歩,特にコルチコステロイドと抗代謝剤は,時間の経過とともに生存率を向上させ,発病率を低下させました.
結論:
- 小児性SLEは,発症年齢と特定の臓器の関与によって影響を受け,予後が警戒される重症疾患です.
- コルチコステロイドや潜在的に抗代謝物質を含む早期認識と積極的な管理は,小児性SLEのアウトカムを改善するために不可欠です.
- 小児の自己免疫疾患については,ホルモンの影響と新しい治療戦略に関するさらなる研究が必要である.
関連する概念動画
Smooth Endoplasmic Reticulum
Smooth endoplasmic reticulum or smooth ER is a sub-organelle with specialized functions in animal cells and plant cells. It is often associated with the tubule morphology of the endoplasmic reticulum.
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...
Connective Tissue Cell Types
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Collagens are the Major Structural Proteins of ECM
Three main types of fibers are secreted by fibroblasts: collagen fibers, elastic fibers, and reticular fibers. Collagen fiber is made from fibrous protein subunits linked together to form a long, straight fiber. Collagen fibers, while flexible, have great tensile strength, resist stretching, and give ligaments and tendons their characteristic resilience and strength. These fibers hold connective tissues together, even during the body's movement.
Connective tissue proper includes loose...
Connective tissue proper includes loose...
Fibril-associated Collagen
Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
Type IV Collagen of Basal Lamina
Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can exist in...
A type IV collagen molecule has six alpha chains which can exist in...
Introduction to Connective Tissues
Connective tissues are one of the four main tissue types in humans that are extensively present in the body. They are characterized by cells embedded in an extracellular matrix (ECM) composed of a ground substance and three main types of protein fibers— collagen, elastic, and reticular fibers. The ground substance of connective tissues can range from a watery and jelly-like consistency to mineralized and hard. The wide variety of cells in the connective tissues include fibroblasts, osteocytes,...

