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Updated: Aug 12, 2026

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
15:07

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

Published on: December 28, 2015

新しい免疫グロブリン重鎖は,リンパ性細胞のDJH遺伝子セグメントの再編成によって生成されます

M G Reth, F W Alt

    Nature
    |November 5, 1984
    PubMed
    まとめ

    ほとんどの免疫グロブリン重鎖遺伝子多様性 (D) セグメントは,5'プロモーターを持っています. これにより,DmuメッセンジャーRNAへの転写が可能になり,Bリンパ球細胞の変数N端を持つDmuタンパク質を生成する可能性があります.

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    Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches09:35

    Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches

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