ニュー腫瘍遺伝子は,Erb-Bに関連した遺伝子で,185,000-Mr腫瘍抗原をコードする
Nature
|December 6, 1984
まとめ
ネズミの神経/膠芽細胞は,腫瘍抗原 (p185) を生成する共通の変異遺伝子 (neu) を共有しています. この抗原は表皮成長因子 (EGF) 受容体と関連しているが,両タンパク質が正常なネズミの細胞に存在するため,異なっている.
科学分野:
- 腫瘍学 腫瘍学
- 分子生物学は分子生物学である.
- がん遺伝学 がん遺伝学
背景:
- ネズミの神経/膠芽細胞腫は,特定の変異遺伝子が特徴です.
- neu腫瘍遺伝子は,erb-B遺伝子の同型である.
- 腫瘍抗原であるp185は,これらの膠原腫と関連しています.
研究 の 目的:
- ネズミの神経/膠芽細胞腫の変異遺伝子を特定するために.
- neu腫瘍遺伝子が誘発した腫瘍抗原を特徴付けるために.
- ニュー誘発腫瘍抗原と表皮成長因子 (EGF) 受容体との関係を調査する.
主な方法:
- ネズミのニューロ/グリオブラストーマの遺伝子変異の分析.
- 腫瘍抗原を検出し,特徴づけるために免疫学的測定法.
- ニュー誘発抗原とEGF受容体の比較.
主要な成果:
- 共通の変異遺伝子であるneuは,すべての試験されたネズミの神経/膠芽細胞腫で特定されました.
- ニュー腫瘍遺伝子は,相対分子量185,000 (p185) の腫瘍抗原の合成を誘導する.
- p185腫瘍抗原はEGF受容体と血清学的に関連しているが,それらは異なったタンパク質であり,その証拠は変異していないラット-1細胞の共存である.
結論:
- このニュー腫瘍遺伝子は,ネズミの神経/膠芽細胞腫の発症において重要な役割を果たします.
- p185抗原は,ノイ誘発変異に関連した特定の腫瘍マーカーです.
- 新型原発がん遺伝子製品は,EGF受容体とは異なるが,EGF受容体と関連している.
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