11週間のエイコサペンタエノ酸の摂取量の増加が出血時間,脂質,血小板の集積に及ぼす影響
Lancet (London, England)
|November 28, 1981
まとめ
エイコサペンタエノ酸 (EPA) を多く含有する魚に富んだ食事は,出血時間を延長し,血小板の蓄積を減少させた. これらの効果は,一般的な薬に対する血小板の感受性の単純な変化を超えた複雑なメカニズムを示唆しています.
科学分野:
- 心血管科学 心血管科学
- 栄養科学 栄養学 栄養科学は,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学は,栄養学が,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は
- 血液学 ヘマトロジ
背景:
- オメガ3脂肪酸,特にエコサペンタエノ酸 (EPA) の食事摂取は,心臓血管の健康に影響することが知られている.
- 血小板の機能は,血液静止と血栓形成において極めて重要であり,食事要因による血小板の調節は,活発な研究分野である.
研究 の 目的:
- 健康な男性における血小板ホルモン脂肪酸の組成,血小板の集積,出血時間に対するEPA豊富な魚の食事の影響を調査する.
- このダイエットとアセチルサリチル酸 (ASA) がこれらのパラメータに及ぼす影響の組み合わせを検証する.
主な方法:
- 10人の健康な男性は,魚に部分的に置き換えられた食事を11週間摂取し,毎日2〜3gのEPAを提供しました.
- アセチルサリシル酸 (ASA) は,食事介入前およびその間,2つの投与量 (3.5mgおよび10mg/kg) で投与されました.
- 測定には,血小板のリンパ脂脂肪酸の成分,血小板の集積 (コラーゲンとADPによって誘発される),出血時間などが含まれていた.
主要な成果:
- EPAに富んだ食事は出血時間を (42%) 大幅に延長し,血小板の結合性を低下させた.
- 血小板のリンパ脂はオメガ3脂肪酸の増加 (C20:5,C22:6) とオメガ6脂肪酸の減少 (C18:2,C20:3) を示した.
- 血小板のコラーゲン結合の減少は一時的であったが,ADPに対する感受性の低下はダイエット後も続いた.
結論:
- EPAのようなオメガ3多不飽和脂肪酸に富んだ食事は,血管壁との血小板の相互作用を減らすことができます.
- 関連するメカニズムは複雑で,コラーゲンとADPまたはプロスタグランジンバランスに対する血小板の反応の単純な変化を超えて広がっています.
- ダイエットによるEPAとASAは出血時間に対して相乗効果を発揮し,血小板機能に対する両者の影響が強調されています.
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